Family MED6

MED6 is an essential for viability component of the head module of the yeast mediator complex. It is involved in bridging between the head and tail modules of mediator. A mutation of MED6 in yeast abolished activation of transcription of 5 inducible promoters in vivo, but this mutation had no effect on uninduced transcription, transcription of constitutively expressed genes, or transcription by RNA polymerases I and III (PMID:9234719). MED6 specifically interacts with Srb4, and this interaction is a requirement for transcriptional regulation of the RNA pol II holoenzyme (PMID:9710620).